SPION size dependent effects on normal and cancer cells

Authors

  • Sergiu Gabriel MACAVEI Department of Mechatronics and Machine Dynamics, Faculty of Mechanical Engineering, Technical University, 103-105 Muncii Bvd., 400641, Cluj-Napoca, Romania; National Institute of Research and Development for Isotopic and Molecular Technologies, 67-103 Donath Str., 400293, Cluj-Napoca, Romania. https://orcid.org/0000-0001-6367-2398
  • Maria SUCIU National Institute of Research and Development for Isotopic and Molecular Technologies, 67-103 Donath Str., 400293, Cluj-Napoca, Romania; Faculty of Biology and Geology, Babes-Bolyai University, 5-7 Clinicilor Str., 400006, Cluj-Napoca, Romania. *Corresponding author: maria.suciu5@gmail.com https://orcid.org/0000-0001-5449-9108
  • Izabell CRĂCIUNESCU National Institute of Research and Development for Isotopic and Molecular Technologies, 67-103 Donath Str., 400293, Cluj-Napoca, Romania; Faculty of Biology and Geology, Babes-Bolyai University, 5-7 Clinicilor Str., 400006, Cluj-Napoca, Romania. https://orcid.org/0000-0003-0867-8441
  • Lucian BARBU-TUDORAN National Institute of Research and Development for Isotopic and Molecular Technologies, 67-103 Donath Str., 400293, Cluj-Napoca, Romania; Faculty of Biology and Geology, Babes-Bolyai University, 5-7 Clinicilor Str., 400006, Cluj-Napoca, Romania. https://orcid.org/0000-0003-0360-016X
  • Septimiu Cassian TRIPON National Institute of Research and Development for Isotopic and Molecular Technologies, 67-103 Donath Str., 400293, Cluj-Napoca, Romania; Faculty of Biology and Geology, Babes-Bolyai University, 5-7 Clinicilor Str., 400006, Cluj-Napoca, Romania.
  • Cristian LEOȘTEAN National Institute of Research and Development for Isotopic and Molecular Technologies, 67-103 Donath Str., 400293, Cluj-Napoca, Romania. https://orcid.org/0000-0002-4346-5006
  • Radu BĂLAN Department of Mechatronics and Machine Dynamics, Faculty of Mechanical Engineering, Technical University, 103-105 Muncii Bvd., 400641, Cluj-Napoca, Romania. https://orcid.org/0000-0003-2416-3819

DOI:

https://doi.org/10.24193/subbb.2017.1.02

Keywords:

hyperthermia, melanoma cells, SPION.

Abstract

Iron oxide nanoparticles have become widely used today in medical applications. In this study, we report a hyperthermia treatment with 10 and 100 nm naked and polyethylene glycol(PEG)-coated Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) to normal and tumor cells in culture. Cells’ responses to nanoparticles were analyzed by cell viability assays (MTT and LDH) and transmission electron microscopy. Results indicate that even if 10 nm SPIONs have good magnetization saturation, the hyperthermia treatment is not effective due to the fact that cells do not endocytose them. 100 nm SPIONs are better engulfed by cells, and their hyperthermia effect is slightly increased.

Macavei et al (PDF)

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Published

2017-06-20

Issue

Vol. 62 No. 1 (2017)

Section

Research article

License

Copyright (c) 2017 Studia Universitatis Babeș-Bolyai Biologia. Published by Babeş-Bolyai University

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