Natural strategies of preventing anthracycline-induced cardiotoxicity – a review


  • Anca Stoica Babeș-Bolyai University, Cluj-Napoca, Cluj; National Institute of Research and Development of Isotopic and Molecular Technology, Cluj-Napoca, Cluj; 3B Centre for Systems Biology, Biodiversity and Bioresources, Cluj-Napoca.
  • Camelia Dobre Babeș-Bolyai University, Cluj-Napoca, Cluj; 3B Centre for Systems Biology, Biodiversity and Bioresources, Cluj-Napoca. *Corresponding author:



cardiotoxicity, antioxidants, prevention, polyphenols


Cardiotoxicity is one of the worst long-term effects of cancer therapy and doxorubicin is one of the main compounds responsible for cardiovascular complications. There are several biologically active compounds that can alleviate or prevent cardiotoxicity through multiple directions. Therefore, one of the aims of this paper is to emphasize the mechanisms by which several naturally occuring substances can improve the cardiac activity after drug-induced cardiotoxicity. The second part of this paper aims to update the molecular mechanism by which physical exercise and nutrition improve the life of a person with cardiovascular disease. The data collected showed that an active life and following a diet rich in polyphenols, coenzyme Q10, magnesium, may enhance the cardiovascular activity after exposure cu cardiotoxic drugs.



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