MATN1 gene variant (rs1065755) and malocclusion risk: Evidence from Romanian population analysis
DOI:
https://doi.org/10.24193/subbbiol.2024.1.09Keywords:
malocclusion, MATN1, rs1065755, cephalometric measurementsAbstract
Malocclusion, characterized by its diverse phenotypic expression, significantly impacts patients’ quality of life. Over recent years, extensive attention has been directed towards the genetic basis of this condition, particularly focusing on various polymorphisms of the MATN1 gene. Among these, the rs1065755 polymorphism has emerged as particularly relevant, associated with an elevated risk of mandibular prognathism. In this study, employing DNA sequencing, we investigated the extent of association between the rs1065755 SNP and malocclusion risk within the Romanian population. Our approach concentrated on assessing continuous phenotypic variation through four cephalometric measurements, aiming for a comprehensive understanding beyond categorical phenotypes. The findings shed light on the relationship between the MATN1 rs1065755 SNP and the investigated dentofacial disorder, revealing a positive association between TT homozygous individuals and Class II skeletal malocclusion. However, further investigations employing larger sample sizes are necessary to validate these findings conclusively.
References
Balkhande, P.B., Lakkakula, B.V.K.S. & Chitharanjan, A.B. (2018). Relationship between matrilin-1 gene polymorphisms and mandibular retrognathism. Am J Orthod Dentofacial Orthop. 153, 2, 255-261 e1, Doi: 10.1016/j.ajodo.2017.06.023.
Buschang, P.H. (2014). Class I malocclusions—The development and etiology of mandibular malalignments. Seminars in Orthodontics. 20, 1, 3-15, Doi: 10.1053/j.sodo.2013.12.002.
Dehesa-Santos, A., Iber-Diaz, P. & Iglesias-Linares, A. (2021). Genetic factors contributing to skeletal class III malocclusion: a systematic review and meta-analysis. Clin Oral Investig. 25, 4, 1587-1612, Doi: 10.1007/s00784-020-03731-5.
Doraczynska-Kowalik, A., Nelke, K.H., Pawlak, W., Sasiadek, M.M. & Gerber, H. (2017). Genetic factors involved in mandibular prognathism. J Craniofac Surg. 28, 5, e422-e431, Doi: 10.1097/SCS.0000000000003627.
George, A.M., Felicita, A.S., Milling Tania, S.D. & Priyadharsini, J.V. (2021). Systematic review on the genetic factors associated with skeletal Class II malocclusion. Indian J Dent Res. 32, 3, 399-406, Doi: 10.4103/ijdr.IJDR_59_20.
Ghergie, M., Festila, D., Kelemen, B. & Lupan, I. (2013a). Myo1H gene single nucleotide polymorphism rs10850110 and the risk of malocclusion in the romanian population. Acta Medica Transilvanica. 2, 4, 281-284.
Ghergie, M., Feştila, D., Lupan, I., Popescu, O. & Kelemen, B.S. (2013b). Testing the association between orthodonthic classes I, II, III and SNPs (rs731236, rs8004560, rs731236) in a Romanian clinical sample. Ann Romanian Soc Cell Biol. 18, 2, 43-51.
Graber, L., Rl, J., Vanarsdall, Kwl, V. & Gj., H. (2017). Orthodontics: current principles and techniques. 6th Ed. Elsevier St. Louis, Missouri, pp. 928.
Hall, T. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucleic Acids Symp. Ser., 1999. 95-98.
Hardy, D.K., Cubas, Y.P. & Orellana, M.F. (2012). Prevalence of angle class III malocclusion: A systematic review and meta-analysis. Open J. Epidemiol. 2, 4, 75-82, Doi: 10.4236/ojepi.2012.24012.
Jang, J.Y., Park, E.K., Ryoo, H.M., Shin, H.I., Kim, T.H., Jang, J.S., Park, H.S., Choi, J.Y. & Kwon, T.G. (2010). Polymorphisms in the Matrilin-1 gene and risk of mandibular prognathism in Koreans. J Dent Res. 89, 11, 1203-7, Doi: 10.1177/0022034510375962.
Kulkarni, S.D., Bhad, W.A. & Doshi, U.H. (2020). Association between mandibular Prognathism and MATRILIN-1 gene in Central India population: A cross-sectional study. J Indian Orthod Soc. 55, 1, 28-32, Doi: 10.1177/0301574220956421.
Laviana, A., Thahar, B., Melani, A., Mardiati, E., Putri, L. & Zakyah, A.D. (2021). Role of matrilin-1 (MATN1) polymorphism in class III skeletal malocclusion with mandibular prognathism in Deutero-Malay race: a case-control study. Egyptian J Med Human. 22, 1, Doi: 10.1186/s43042-021-00131-6.
Li, Q., Zhang, F., Li, X. & Chen, F. (2010). Genome scan for locus involved in mandibular prognathism in pedigrees from China. PloS one. 5, 9, 1-4, Doi: 10.1371/journal.pone.0012678.
Liu, Z., Mcgrath, C. & Hagg, U. (2009). The impact of malocclusion/orthodontic treatment need on the quality of life. A systematic review. Angle Orthod. 79, 3, 585-91, Doi: 10.2319/042108-224.1.
Lone, I.M., Zohud, O., Nashef, A., Kirschneck, C., Proff, P., Watted, N. & Iraqi, F.A. (2023). Dissecting the complexity of skeletal-malocclusion-associated phenotypes: mouse for the rescue. Int J Mol Sci. 24, 3, Doi: 10.3390/ijms24032570.
Ma, J., Huang, J. & Jiang, J.H. (2019). Morphological analysis of the alveolar bone of the anterior teeth in severe high-angle skeletal Class II and Class III malocclusions assessed with cone-beam computed tomography. PloS one. 14, 3, e0210461, Doi: 10.1371/journal.pone.0210461.
Mokhtar, K.I., Abu Bakar, N. & Md Ali Tahir, A.H. (2020). Genetics of malocclusion: A review. IIUM Journal of Orofacial and Health Sciences. 1, 1, 1-6, Doi: 10.31436/ijohs.v1i1.2.
Moreno Uribe, L.M. & Miller, S.F. (2015). Genetics of the dentofacial variation in human malocclusion. Orthod Craniofac Res. 18 Suppl 1, 01, 91-99, Doi: 10.1111/ocr.12083.
Nishio, C. & Huynh, N. (2016). Skeletal malocclusion and genetic expression: An evidence-based review. J dent Sleep. 3, 2, 57-63, Doi: 10.15331/jdsm.5720.
Pei, M., Luo, J. & Chen, Q. (2008). Enhancing and maintaining chondrogenesis of synovial fibroblasts by cartilage extracellular matrix protein matrilins. Osteoarthritis Cartilage. 16, 9, 1110-7, Doi: 10.1016/j.joca.2007.12.011.
Phan, L., Jin, Y., Zhang, H., Qiang, W., Shekhtman, E., Shao, D., Revoe, D., Villamarin, R., Ivanchenko, E. & Kimura, M. (2020). ALFA: allele frequency aggregator. National Center for Biotechnology Information, US National Library of Medicine. 10.
R Core, T. 2020. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing.
Rathod, N., Patel, P., Shah, H.T. & Thakar, M. (2023). Association between mandibular prognathism and MATRILIN-1 gene. NeuroQuantology. 21, 3, 300-306, Doi: 10.48047/NQ.2023.21.3.NQ33032.
Stokes, D.G., Liu, G., Coimbra, I.B., Piera-Velazquez, S., Crowl, R.M. & Jimenez, S.A. (2002). Assessment of the gene expression profile of differentiated and dedifferentiated human fetal chondrocytes by microarray analysis. Arthritis Rheum. 46, 2, 404-19, Doi: 10.1002/art.10106.
Subono, M., Alima, I.R.N. & Auerkari, E.I. (2021). Genetics and epigenetics of class II and class III malocclusions. J Phys Conf Ser 1943, 1, 012091, Doi: 10.1088/1742-6596/1943/1/012091.
Topârcean, A.M., Acatrinei, A., Rusu, I., Mircea, C., Feștilă, D.G., Lucaciu, O.P., Cȃmpian, R.S., Bodo, O., Kelemen, B.S. & Ghergie, M. (2021). Preliminary data regarding the influence of the COL1a1 rs2249492 polymorphism on the risk of malocclusion in the Romanian population. Stud Univ Babeş-Bolyai Biol. 66, 2, 45-51, Doi: 10.24193/subbbiol.2021.2.03.
Weaver, C.A., Miller, S.F., Da Fontoura, C.S., Wehby, G.L., Amendt, B.A., Holton, N.E., Allareddy, V., Southard, T.E. & Moreno Uribe, L.M. (2017). Candidate gene analyses of 3-dimensional dentoalveolar phenotypes in subjects with malocclusion. Am J Orthod Dentofacial Orthop. 151, 3, 539-558, Doi: 10.1016/j.ajodo.2016.08.027.
Yadav, D., Rani, M., Shailaja, A., Anand, D., Sood, N. & Gothi, R. (2014). Angle’s molar classification revisited. J Indian Orthod Soc. 48, 4_suppl2, 382-387, Doi: 10.5005/jp-journals-10021-1282.
Yamaguchi, T., Park, S.B., Narita, A., Maki, K. & Inoue, I. (2005). Genome-wide linkage analysis of mandibular prognathism in Korean and Japanese patients. J Dent Res. 84, 3, 255-9, Doi: 10.1177/154405910508400309.
Zabrina, S., Ramadhanti, Jazaldi, F., Gultom, F.P. & Auerkari, E.I. (2021). Genetic and epigenetic aspects of class III malocclusion with mandibular prognathism phenotypes. AIP Conf. Proc. 2344, 1, 10-16, Doi: 10.1063/5.0047282.
Zohud, O., Lone, I.M., Midlej, K., Obaida, A., Masarwa, S., Schroder, A., Kuchler, E.C., Nashef, A., Kassem, F., Reiser, V., Chaushu, G., Mott, R., Krohn, S., Kirschneck, C., Proff, P., Watted, N. & Iraqi, F.A. (2023). Towards genetic dissection of skeletal class III malocclusion: a review of genetic variations underlying the phenotype in humans and future directions. J Clin Med. 12, 9, 3212, Doi: 10.3390/jcm12093212.
Downloads
Published
License
Copyright (c) 2024 Studia Universitatis Babeş-Bolyai Biologia
![Creative Commons License](http://i.creativecommons.org/l/by-nc-nd/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.